Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component, transferring information toward downstream response regulators (RR). HKs transfer phosphoryl groups to their specific RRs, but also dephosphorylate the...

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Bibliographic Details
Main Authors: Felipe Trajtenberg, Juan A Imelio, Matías R Machado, Nicole Larrieux, Marcelo A Marti, Gonzalo Obal, Ariel E Mechaly, Alejandro Buschiazzo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
two component systems
cell signaling
structural biology
allosteric control of protein function
phosphoryl-transfer mechanism
Online Access:https://elifesciences.org/articles/21422

Internet

https://elifesciences.org/articles/21422

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