A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

This work describes the conception, synthesis, in vitro and in vivo biological evaluation of novel Multi-Target Directed Ligands (MTDL) able to both activate 5-HT4 receptors, block 5-HT6 receptors and inhibit acetylcholinesterase activity (AChE), in order to exert a synergistic anti-amnesic effect,...

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Bibliographic Details
Main Authors: Bérénice Hatat, Samir Yahiaoui, Cédric Lecoutey, Audrey Davis, Thomas Freret, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
acetylcholinesterase
5-HT4 receptors
5-HT6 receptors
MTDL
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00148/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00148/full

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