Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common type of dementia. AD is characterized by a decline of cognitive function and brain atrophy, and is highly heritable with estimated heritability ranging from 60 to 80 $$\%$$ % . The most straightf...

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Bibliographic Details
Main Authors: Mansu Kim, Ruiming Wu, Xiaohui Yao, Andrew J. Saykin, Jason H. Moore, Li Shen, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Medical Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12920-022-01323-8