PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

Summary: Oxidative/nitrosative stress is a major trigger of cardiac dysfunction, involving the unfolded protein response and mitochondrial dysfunction. Activation of nitric oxide-cyclic guanosine monophosphate-protein kinase G signaling by sildenafil improves cardiac mal-remodeling during pressure-o...

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Bibliographic Details
Main Authors: Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Naoko Takubo, Yasuharu Kanki, Yoshihiro Urade, Youichiro Wada
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306003

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http://www.sciencedirect.com/science/article/pii/S2589004220306003

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