Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus

Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus

ABSTRACT Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides. Following this metabolic shift, high concentration...

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Bibliographic Details
Main Authors: William N. Beavers, Matthew J. Munneke, Alex R. Stackhouse, Jeffrey A. Freiberg, Eric P. Skaar
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
MRSA
PUFA
Staphylococcus aureus
aminoglycoside
antibiotic tolerance
arachidonic acid
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02767-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02767-21

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