Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

ABSTRACT Copper is well known for its antimicrobial and antiviral properties. Under aerobic conditions, copper toxicity relies in part on the production of reactive oxygen species (ROS), especially in the periplasmic compartment. However, copper is significantly more toxic under anaerobic conditions...

Full description

Bibliographic Details
Main Authors: Lisa Zuily, Nora Lahrach, Rosi Fassler, Olivier Genest, Peter Faller, Olivier Sénèque, Yann Denis, Marie-Pierre Castanié-Cornet, Pierre Genevaux, Ursula Jakob, Dana Reichmann, Marie-Thérèse Giudici-Orticoni, Marianne Ilbert
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
copper stress
molecular chaperone
protein aggregation
copper homeostasis
Escherichia coli
DnaK
Online Access:https://journals.asm.org/doi/10.1128/mbio.03251-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03251-21

Similar Items