Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Abstract Background To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However, identifying tractable nodes of metabolic vulnerability in cancer cell...

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Bibliographic Details
Main Authors: Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams, Emma E. Vincent
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cancer & Metabolism
Subjects:
Colorectal cancer
Aspirin
Metabolism
Metabolic reprogramming
CB-839
Glutaminase
Online Access:https://doi.org/10.1186/s40170-023-00318-y

Internet

https://doi.org/10.1186/s40170-023-00318-y

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