Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche

Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche

ABSTRACT Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death. Thus, bacterial regulation of CCV cholesterol content is es...

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Bibliographic Details
Main Authors: Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
Coxiella
cholesterol
intracellular pathogen
vacuoles
vesicular trafficking
Online Access:https://journals.asm.org/doi/10.1128/mbio.03073-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03073-21

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