Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners

Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners

Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling pathway, PHD2 is generally regarded...

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Bibliographic Details
Main Authors: Hongyan Deng, Zixuan Wang, Chunchun Zhu, Zhu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Oncology
Subjects:
PHD2
prolyl hydroxylase
non-small cell lung cancer
HIF-dependent
HIF-independent
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1370393/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1370393/full

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