Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling pathway, PHD2 is generally regarded...
| Main Authors: | , , , |
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| 格式: | 文件 |
| 语言: | English |
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Frontiers Media S.A.
2024-06-01
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| 丛编: | Frontiers in Oncology |
| 主题: | |
| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1370393/full |