The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties

The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties

Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-suppor...

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Main Authors: Alessandro Colapietro, Peiying Yang, Alessandra Rossetti, Andrea Mancini, Flora Vitale, Stefano Martellucci, Tara L. Conway, Sharmistha Chakraborty, Francesco Marampon, Vincenzo Mattei, Giovanni Luca Gravina, Assunta Leda Biordi, Daoyan Wei, Robert A. Newman, Claudio Festuccia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
glioblastoma stem cells
PBI-05204
PI3k/mTOR
Nerium oleander
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.552428/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.552428/full

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