Addressing the role of PKD3 in the T cell compartment with knockout mice

Addressing the role of PKD3 in the T cell compartment with knockout mice

Abstract Background The Protein kinase D3 (PKD3) has been implicated in signal transduction downstream of the T cell receptor (TCR). However, its role for the activation of primary T lymphocytes has not been elucidated so far. Methods Expression of PKD isoforms in primary murine T cells was determin...

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Bibliographic Details
Main Authors: Jiří Koutník, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier, Kerstin Siegmund
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell Communication and Signaling
Subjects:
T lymphocyte
TCR signaling and activation
Protein kinase D
PKD
Online Access:https://doi.org/10.1186/s12964-022-00864-w

Internet

https://doi.org/10.1186/s12964-022-00864-w

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