Annexin A1 Tripeptide Mimetic Increases Sirtuin-3 and Augments Mitochondrial Function to Limit Ischemic Kidney Injury

Annexin A1 Tripeptide Mimetic Increases Sirtuin-3 and Augments Mitochondrial Function to Limit Ischemic Kidney Injury

Background: Acute kidney injury (AKI) is one of the most common organ failures following surgery. We have developed a tripeptide mimetic (ANXA1sp) of the parent annexin A1 molecule that shows promise as an organ protectant limiting cellular stress; however, its potential as a kidney protective agent...

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Bibliographic Details
Main Authors: Hagir Suliman, Qing Ma, Zhiquan Zhang, Jiafa Ren, Benjamin T. Morris, Steven D. Crowley, Luis Ulloa, Jamie R. Privratsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
acute kidney injury
mitochondrial integrity
sirtuin 3
ischemia/reperfusion injury
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.683098/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.683098/full

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