Evaluation of Microsatellite Instability Molecular Analysis versus Immuno-Histochemical Interpretation in Malignant Neoplasms with Different Localizations

Evaluation of Microsatellite Instability Molecular Analysis versus Immuno-Histochemical Interpretation in Malignant Neoplasms with Different Localizations

MMR gene germline mutations are considered a major genetic disorder in patients with hereditary nonpolyposis colon cancer (HNPCC) or Lynch syndrome; A total of 15% of sporadic colon carcinomas are MSI-High. MSI has also been observed in other cancers, such as endometrial, gastric, and ovarian cancer...

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Bibliographic Details
Main Authors: Maria Sfakianaki, Maria Tzardi, Konstantina Tsantaki, Chara Koutoulaki, Ippokratis Messaritakis, Galateia Datseri, Eleni Moustou, Dimitrios Mavroudis, John Souglakos
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
microsatellite instability
colorectal cancer
MMR proteins
fragment analysis
<i>MSH2</i>
<i>MLH1</i>
Online Access:https://www.mdpi.com/2072-6694/15/2/353

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https://www.mdpi.com/2072-6694/15/2/353

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