Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN

Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN

Dopamine (D2) receptors provide autoinhibitory feedback onto dopamine neurons through well-known interactions with voltage-gated calcium channels and G protein-coupled inwardly-rectifying potassium (GIRK) channels. Here, we reveal a third major effector involved in D2R modulation of dopaminergic neu...

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Bibliographic Details
Main Authors: Fabian Philippart, Zayd M Khaliq
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
dopamine neurons
sodium leak channel
Gi/o protein-coupled receptor
GABA-B receptors
D2 receptors
substantia nigra
Online Access:https://elifesciences.org/articles/40984

Internet

https://elifesciences.org/articles/40984

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