Small and long RNA transcriptome of whole human cerebrospinal fluid and serum as compared to their extracellular vesicle fractions reveal profound differences in expression patterns and impacts on biological processes

Small and long RNA transcriptome of whole human cerebrospinal fluid and serum as compared to their extracellular vesicle fractions reveal profound differences in expression patterns and impacts on biological processes

Abstract Background Next generation sequencing (NGS) of human specimen is expected to improve prognosis and diagnosis of human diseases, but its sensitivity urges for well-defined sampling and standardized protocols in order to avoid error-prone conclusions. Methods In this study, large volumes of p...

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Bibliographic Details
Main Authors: Uwe Michel, Orr Shomroni, Barbara Müller, Peter Lange, Gabriela Salinas, Mathias Bähr, Jan Christoph Koch
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Translational Medicine
Subjects:
Human cerebrospinal fluid
Human serum
Extracellular vesicles
Small and long RNA transcriptome
RNA expression patterns
Online Access:https://doi.org/10.1186/s12967-022-03612-3

Internet

https://doi.org/10.1186/s12967-022-03612-3

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