Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen

Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen

Tamoxifen (TAM) is widely used in the treatment of hormone receptor-positive breast cancer. TAM is metabolized into the active secondary metabolite endoxifen (ENDO), primarily by CYP2D6. We aimed to investigate the effects of an African-specific <i>CYP2D6</i> variant allele, <i>CYP...

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Bibliographic Details
Main Authors: Comfort Ropafadzo Kanji, Georginah Nyabadza, Charles Nhachi, Collen Masimirembwa
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Journal of Personalized Medicine
Subjects:
tamoxifen
pharmacogenetics
<i>CYP2D6*17</i>
genetic polymorphism
pharmacokinetics
metabolism
Online Access:https://www.mdpi.com/2075-4426/13/2/272

Internet

https://www.mdpi.com/2075-4426/13/2/272

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