A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydros...

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Bibliographic Details
Main Authors: Philippe FY Vincent, Yohan Bouleau, Christine Petit, Didier Dulon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
exocytosis
hair cell
actin network
osmotic pressure
Online Access:https://elifesciences.org/articles/10988

Internet

https://elifesciences.org/articles/10988

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