Impaired Wheel Running Exercise in CLC-1 Chloride Channel-Deficient Myotonic Mice

Background: Genetic deficiency of the muscle CLC-1 chloride channel leads to myotonia, which is manifested most prominently by slowing of muscle relaxation. Humans experience this as muscle stiffness upon initiation of contraction, although this can be overcome with repeated efforts (the warm-up p...

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Bibliographic Details
Main Authors: Erik eVan Lunteren, Michelle eMoyer, Jessica eCooperrider, Jennifer ePollarine
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00047/full