Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

Abstract Background Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway inflammation, airflow obstruction, and frequent exacerbations....

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Bibliographic Details
Main Authors: Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Respiratory Research
Subjects:
TNFα
IFNγ
Corticosteroids
Airway smooth muscle
Online Access:https://doi.org/10.1186/s12931-022-02046-1

Internet

https://doi.org/10.1186/s12931-022-02046-1

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