Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP)

Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP)

Abstract Background Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead to drug resistance by pumping PTX out of GC cells. Consequently, it might be a hopeful way to combat drug resistance by inhibiting the out-pumping...

Full description

Bibliographic Details
Main Authors: Weihong Guo, Zhian Chen, Xiaoli Feng, Guodong Shen, Huilin Huang, Yanrui Liang, Bingxia Zhao, Guoxin Li, Yanfeng Hu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Nanobiotechnology
Subjects:
Graphene oxide (GO)
Drug resistance
P-glycoprotein (P-gp)
Chemo/photothermal (PTT)/photodynamic (PDT) therapy
Mitochondrial respiratory chain
Online Access:https://doi.org/10.1186/s12951-021-00874-9

Internet

https://doi.org/10.1186/s12951-021-00874-9

Similar Items