Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo.

Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo.

<h4>Purpose</h4>To test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.<h4>Methods</h4>Intraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) or saline...

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Main Authors: Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226840&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226840&type=printable

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