Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo.

<h4>Purpose</h4>To test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.<h4>Methods</h4>Intraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) or saline...

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Main Authors: Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts
פורמט: Article
שפה:English
יצא לאור: Public Library of Science (PLoS) 2020-01-01
סדרה:PLoS ONE
גישה מקוונת:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226840&type=printable