Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop

The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic r...

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Bibliographic Details
Main Authors: Orsolya Mózner, Boglárka Zámbó, Zsuzsa Bartos, Anna Gergely, Kata Sára Szabó, Bálint Jezsó, Ágnes Telbisz, György Várady, László Homolya, Tamás Hegedűs, Balázs Sarkadi
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Membranes
Subjects:
ABCG2
BCRP
MXR
multidrug transporter
unstructured loop variants
Online Access:https://www.mdpi.com/2077-0375/13/10/822

Internet

https://www.mdpi.com/2077-0375/13/10/822

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