Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

The majority of human breast cancer is estrogen receptor alpha (ER) positive. While anti-estrogens/aromatase inhibitors are initially effective, resistance to these drugs commonly develops. Therapy-resistant tumors often retain ER signaling, via interaction with critical oncogenic coregulator protei...

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Bibliographic Details
Main Authors: Ganesh V Raj, Gangadhara Reddy Sareddy, Shihong Ma, Tae-Kyung Lee, Suryavathi Viswanadhapalli, Rui Li, Xihui Liu, Shino Murakami, Chien-Cheng Chen, Wan-Ru Lee, Monica Mann, Samaya Rajeshwari Krishnan, Bikash Manandhar, Vijay K Gonugunta, Douglas Strand, Rajeshwar Rao Tekmal, Jung-Mo Ahn, Ratna K Vadlamudi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
estrogen receptor
coregulators
coagulator binding modulator
endocrine therapy
breast cancer
Online Access:https://elifesciences.org/articles/26857

Internet

https://elifesciences.org/articles/26857

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