Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses co...

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Bibliographic Details
Main Authors: Laurence Dion-Albert, Alice Cadoret, Ellen Doney, Fernanda Neutzling Kaufmann, Katarzyna A. Dudek, Beatrice Daigle, Lyonna F. Parise, Flurin Cathomas, Nalia Samba, Natalie Hudson, Manon Lebel, Signature Consortium, Matthew Campbell, Gustavo Turecki, Naguib Mechawar, Caroline Menard
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27604-x

Internet

https://doi.org/10.1038/s41467-021-27604-x

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