Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells

Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells

Abstract Background Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochemical cues, the stiffness of a substrate that cells attach to has also b...

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Bibliographic Details
Main Authors: Shiqi Xiang, Zhong Li, Madalyn R. Fritch, La Li, Sachin Velankar, Yuwei Liu, Jihee Sohn, Natasha Baker, Hang Lin, Rocky S. Tuan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Substrate stiffness
Photocrosslinked gelatin hydrogel
Adipogenesis
YAP
CAV1
Online Access:https://doi.org/10.1186/s13287-021-02356-z

Internet

https://doi.org/10.1186/s13287-021-02356-z

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