Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

(1) Background: Colorectal cancer (CRC) is a common gastrointestinal malignancy, accounting for the second largest gastrointestinal tumor. MORC2, a newly discovered chromatin remodeling protein, plays an important role in the biological processes of various cancers. However, the potential mechanisti...

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Bibliographic Details
Main Authors: Kepeng Ou, Youjian Li, Yiling Long, Yafei Luo, Dianyong Tang, Zhongzhu Chen
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
MORC2
CRC
tumorgenesis
HDAC4
senescence
Online Access:https://www.mdpi.com/1420-3049/27/19/6247

Internet

https://www.mdpi.com/1420-3049/27/19/6247

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