Introduction of Non-natural Amino Acids Into T-Cell Epitopes to Mitigate Peptide-Specific T-Cell Responses

Introduction of Non-natural Amino Acids Into T-Cell Epitopes to Mitigate Peptide-Specific T-Cell Responses

Non-natural modifications are widely introduced into peptides to improve their therapeutic efficacy, but their impact on immunogenicity remains largely unknown. As the CD4 T-cell response is a key factor in triggering immunogenicity, we investigated the effect of introducing D-amino acids (Daa), ami...

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Bibliographic Details
Main Authors: Aurélien Azam, Sergio Mallart, Stephane Illiano, Olivier Duclos, Catherine Prades, Bernard Maillère
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
non-natural amino acids
immunogenicity
HLA class II molecules
CD4 T-cell response
T-cell epitope
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637963/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.637963/full

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