A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases

A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases

The mechanism of (CAG)n repeat generation, and related expandable repeat diseases in non-dividing cells, is currently understood in terms of a DNA template-based DNA repair synthesis process involving hairpin stabilized slippage, local error-prone repair via MutSβ (MSH2–MSH3) hairpin protective stab...

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Bibliographic Details
Main Authors: Andrew Franklin, Edward J. Steele, Robyn A. Lindley
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Heliyon
Subjects:
Neuroscience
CAG expansions
Huntington's disease
Error-prone DNA repair
AID/APOBEC/ADAR deaminases
DNA polymerase-eta
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020301031

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http://www.sciencedirect.com/science/article/pii/S2405844020301031

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