Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor

Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor

Extracellular adenosine, produced from ATP secreted by neuronal or immune cells, may play a role in endogenous regulation of inflammatory responses. Studies show that adenosine induces hypersecretion of IL-17A by CD4+ T cells upon treatment with an A2aR agonist (PSB0777), and that adenosine-mediated...

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Bibliographic Details
Main Authors: Mieko Tokano, Sho Matsushita, Rie Takagi, Toshimasa Yamamoto, Masaaki Kawano
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Adenosine
Adenosine A2a receptor
CD4+ T cells
IL-17A
Th17 cells
EAE
Online Access:http://www.sciencedirect.com/science/article/pii/S266635462200134X

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http://www.sciencedirect.com/science/article/pii/S266635462200134X

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