The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles of SL have expanded beyond genetic definitions...

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Bibliographic Details
Main Authors: Meiyi Ge, Jian Luo, Yi Wu, Guobo Shen, Xi Kuang
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:MedComm – Oncology
Subjects:
cancer therapy
cell–cell interaction
genome stability
synthetic lethality
tumor microenvironment
Online Access:https://doi.org/10.1002/mog2.70

Internet

https://doi.org/10.1002/mog2.70

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