Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3

Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3

The intracellular retention of mutant cartilage matrix proteins and pathological endoplasmic reticulum (ER) stress disrupts ossification and has been identified as a shared disease mechanism in a range of skeletal dysplasias including short limbed-dwarfism, multiple epiphyseal dysplasia type 5 (EDM5...

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Bibliographic Details
Main Authors: Ella P. Dennis, Robyn N. Watson, Florence McPate, Michael D. Briggs
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
genetic skeletal disease
chondrodysplasia
matrilin-3
endoplasmic reticulum (ER) stress
curcumin
proteasomal degradation
Online Access:https://www.mdpi.com/1422-0067/24/2/1496

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https://www.mdpi.com/1422-0067/24/2/1496

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