Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice

Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice

Purpose: The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to gain insight into its pathophysiology and develop potential therapies. Methods and Results: In our study, the combination of the com...

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Bibliographic Details
Main Authors: Abdulrazaq Alanazi, Mahmoud N. Nagi, Dhafer Y. Alhareth, Mohammed A Al-Hamamah, Mohamed A Mahmoud, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa, Sabry M. Attia
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Saudi Pharmaceutical Journal
Subjects:
Acute hepatic failure
Animal models
Translational study
Caspase-3
Necrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423000130

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http://www.sciencedirect.com/science/article/pii/S1319016423000130

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