Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling

Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling

Three genes, fibrinogen-α (FBGα), -β, and -γ, encode proteins that make up the mature FBG protein complex. This complex is secreted from the liver and plays a key role in coagulation in response to vascular disruption. We identified all three FBG genes in a screen designed to isolate genes that are...

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Bibliographic Details
Main Authors: Andrew M. Anisfeld, Heidi R. Kast-Woelbern, Hans Lee, Yanqiao Zhang, Florence Y. Lee, Peter A. Edwards
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Journal of Lipid Research
Subjects:
farnesoid X receptor
chenodeoxycholic acid
3-(2,6-dichlorophenyl)-4-(3′-carboxy-2-chloro-stilben-4-yl)-oxymethyl-5-isopropyl-isoxazole
nuclear hormone receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752034030X

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http://www.sciencedirect.com/science/article/pii/S002222752034030X

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