Alleviation of cognitive deficits in a rat model of glutamate-induced excitotoxicity, using an N-type voltage-gated calcium channel ligand, extracted from Agelena labyrinthica crude venom

Alleviation of cognitive deficits in a rat model of glutamate-induced excitotoxicity, using an N-type voltage-gated calcium channel ligand, extracted from Agelena labyrinthica crude venom

Excitotoxicity is a common pathological process in Alzheimer’s disease (AD) which is caused by the over-activity of N-Methyl-D-Aspartate receptors (NMDARs). The release of neurotransmitters depends on the activity of voltage-gated calcium channels (VGCCs). Hyper-stimulation of NMDARs can enhance the...

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Bibliographic Details
Main Authors: Mohammad Keimasi, Kowsar Salehifard, Mohammadjavad Keimasi, Mohammadreza Amirsadri, Noushin Mirshah Jafar Esfahani, Majid Moradmand, Fariba Esmaeili, Mohammad Reza Mofid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cognitive dysfunction
spider
calcium channel Cav2.2 (N-type)
learning and memory
venom
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1123343/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1123343/full

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