Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA–protein binding sites

Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA–protein binding sites

Abstract Crosslinking immunoprecipitation sequencing (CLIP-seq) technologies have enabled researchers to characterize transcriptome-wide binding sites of RNA-binding protein (RBP) with high resolution. We apply a soft-clustering method, RBPgroup, to various CLIP-seq datasets to group together RBPs t...

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Bibliographic Details
Main Authors: Yang Eric Li, Mu Xiao, Binbin Shi, Yu-Cheng T. Yang, Dong Wang, Fei Wang, Marco Marcia, Zhi John Lu
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Genome Biology
Subjects:
RNA-binding protein
CLIP-seq
Non-negative matrix factorization
RBPgroup
Online Access:http://link.springer.com/article/10.1186/s13059-017-1298-8

Internet

http://link.springer.com/article/10.1186/s13059-017-1298-8

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