Growth Differentiation Factor 15 Regulates Oxidative Stress-Dependent Ferroptosis Post Spinal Cord Injury by Stabilizing the p62-Keap1-Nrf2 Signaling Pathway

Growth Differentiation Factor 15 Regulates Oxidative Stress-Dependent Ferroptosis Post Spinal Cord Injury by Stabilizing the p62-Keap1-Nrf2 Signaling Pathway

BackgroundSpinal cord injury (SCI) is a severe traumatic disorder of the central nervous system (CNS) that causes irreversible damage to the nervous tissue. The consequent hemorrhage contributed by trauma induces neuronal ferroptosis post SCI, which is an important death mode to mediate neuronal los...

Full description

Bibliographic Details
Main Authors: Mingjie Xia, Qinyang Zhang, Yanan Zhang, Rulin Li, Tianyu Zhao, Lingxia Chen, Qiangxian Liu, Shengnai Zheng, Haijun Li, Zhanyang Qian, Lei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
spinal cord injury
GDF15
oxidative stress
ferroptosis
p62-Keap1-Nrf2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.905115/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.905115/full

Similar Items