Vitamin D metabolism pathway polymorphisms are associated with efficacy and safety in patients under anti-PD-1 inhibitor therapy

Vitamin D metabolism pathway polymorphisms are associated with efficacy and safety in patients under anti-PD-1 inhibitor therapy

AimVitamin D (VitD) signaling has been increasingly investigated for its role in stimulating the innate and adaptive immune systems and suppressing inflammatory responses. Therefore, we examined the associations between VitD-related genetic polymorphisms, plasma 25-hydroxyvitamin D (25(OH)D), and th...

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Bibliographic Details
Main Authors: Jianquan Luo, Huiqing Chen, Fang Ma, Chenlin Xiao, Bao Sun, Yiping Liu, Haoneng Tang, Yue Yang, Wenhui Liu, Zhiying Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors
anti-PD-1 inhibitors
immune-related adverse effects
polymorphism
vitamin D
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.937476/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.937476/full

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