Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis

ABSTRACTColibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis. Patients with inflammatory bowel diseases, such as ulcerative colitis, display changes in their microbiota with th...

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Bibliographic Details
Main Authors: Christine Harnack, Hilmar Berger, Lichao Liu, Hans-Joachim Mollenkopf, Till Strowig, Michael Sigal
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Inflammtory bowel diseases
colitis
microbiota
mucosal barrier
colibactin
E. coli
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2233689

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https://www.tandfonline.com/doi/10.1080/19490976.2023.2233689

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