A new method to investigate how mechanical loading of osteocytes controls osteoblasts

A new method to investigate how mechanical loading of osteocytes controls osteoblasts

Mechanical loading, a potent stimulator of bone formation, is governed by osteocyte regulation of osteoblasts. We developed a 3D in vitro co-culture system to investigate the effect of loading on osteocyte-osteoblast interactions. MLO-Y4 cells were embedded in type I collagen gels and MC3T3-E1(14) o...

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Bibliographic Details
Main Authors: Marisol eVazquez, Bronwen eEvans, Daniela eRiccardi, Sam eEvans, Jim eRalphs, Chris Mark Dillingham, Deborah eMason
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Endocrinology
Subjects:
Osteocyte
Model
osteoblast
co-culture
loading
3 dimensional
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00208/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00208/full

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