Administration of an Acidic Sphingomyelinase (ASMase) Inhibitor, Imipramine, Reduces Hypoglycemia-Induced Hippocampal Neuronal Death

Administration of an Acidic Sphingomyelinase (ASMase) Inhibitor, Imipramine, Reduces Hypoglycemia-Induced Hippocampal Neuronal Death

Severe hypoglycemia (below 35 mg/dL) appears most often in diabetes patients who continuously inject insulin. To rapidly cease the hypoglycemic state in this study, glucose reperfusion was conducted, which can induce a secondary neuronal death cascade following hypoglycemia. Acid sphingomyelinase (A...

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Bibliographic Details
Main Authors: A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Beom Seok Kang, Si Hyun Lee, Sang Won Suh
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
hypoglycemia
sphingolipid
acidic sphingomyelinase
ceramide
imipramine
neuron death
Online Access:https://www.mdpi.com/2073-4409/11/4/667

Internet

https://www.mdpi.com/2073-4409/11/4/667

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