The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool that is used to study the TRPV4 physiological function in vitr...

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Bibliographic Details
Main Authors: Sara Baratchi, Peter Keov, William G. Darby, Austin Lai, Khashayar Khoshmanesh, Peter Thurgood, Parisa Vahidi, Karin Ejendal, Peter McIntyre
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
TRPV4
membrane trafficking
endothelial cells
GSK1016790A
calcium
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00006/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00006/full

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