Cerebrospinal fluid neurofilament dynamic profiles predict cognitive progression in individuals with de novo Parkinson’s disease

Cerebrospinal fluid neurofilament dynamic profiles predict cognitive progression in individuals with de novo Parkinson’s disease

BackgroundNeurofilament light chain protein (NfL) in cerebrospinal fluid (CSF) reflects the severity of neurodegeneration, with its altered concentrations discovered in Parkinson’s disease (PD) and Parkinson’s disease dementia (PD-D).ObjectiveTo determine whether CSF NfL, a promising biomarker of ne...

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Bibliographic Details
Main Authors: Ze-Hu Sheng, Ling-Zhi Ma, Jia-Yao Liu, Ya-Nan Ou, Bing Zhao, Ya-Hui Ma, Lan Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
cerebrospinal fluid
neurofilament light
Parkinson’s progression markers initiative
cognitive decline
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1061096/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.1061096/full

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