Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review
Purpose: Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged chromatin and a decreased ability to repair DNA strand breaks. However, the impact of advanced paternal age on DNA fragmentation remains inconclusive. The aim of the present syste...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2022-01-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| Summary: | Purpose: Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged
chromatin and a decreased ability to repair DNA strand breaks. However, the impact of advanced paternal age on DNA fragmentation
remains inconclusive. The aim of the present systematic review was to investigate the impact of advancing paternal
age (APA) on DNA fragmentation.
Materials and Methods: We conducted a thorough search of listed publications in Scopus, PubMed, and EMBASE, in accordance
with the PRISMA guidelines.
Results: We identified 3,120 articles, of which nineteen were selected for qualitative analysis, resulting in a sample of 40,668
men. Of the 19 articles evaluating the impact of APA on DFI% (DNA fragmentation Index) included, 4 were on Normozoospermic
and subfertile men, 3 on normozoospermic, Oligoasthenoteratozoospermic and Teratozoospermic, 6 on fertile and
infertile men, 4 on just infertile men, and 2 evaluated a general population. Seventeen of the ninrnteen studies demonstrated
APA’s effect and impact on DFI%.
Conclusions: Although there was no universal definition for APA, the present review suggests that older age is associated with
increased DFI. In elderly men with normal semen parameters, further studies should be performed to assess the clinical implications
of DFI, as a conventional semen analysis can often fail to detect an etiology for infertility. |
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| ISSN: | 2287-4208 2287-4690 |