Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase

Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase

In addition to its well-established immunosuppressive actions, tryptophan 2,3-dioxygenase (TDO) appears to elicit direct effects on tumor cell function. Although TDO has been associated with cancer stemness, its involvement in melanoma stem cell biology remains largely unknown. Since we showed that...

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Bibliographic Details
Main Authors: Marta Cecchi, Antonella Mannini, Andrea Lapucci, Angela Silvano, Matteo Lulli, Cristina Luceri, Mario D’Ambrosio, Alberto Chiarugi, Ali H. Eid, Astrid Parenti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
melanoma
SK-MEL-28
A375
dexamethasone
glucocorticoids
tryptophan 2,3 dioxygenase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.911019/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.911019/full

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