TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

Abstract Background Exposure to a harsh ovarian microenvironment induced by chemotherapeutic agents seriously affects the remodeling of ovarian function and follicular development, leading to premature ovarian failure or insufficiency (POF/POI). For decades, the effectiveness of stem cell therapies...

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Bibliographic Details
Main Authors: Yating Huang, Qiuwan Zhang, Wenjiao Cao, Qinyu Zhang, Lulu Wang, Dongmei Lai
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Inflammation and Regeneration
Subjects:
Human amniotic epithelial stem cells
Premature ovarian failure/insufficiency
Inflammatory cytokine
Prestimulation
Paracrine secretion
Oxidative damage
Online Access:https://doi.org/10.1186/s41232-023-00309-y

Internet

https://doi.org/10.1186/s41232-023-00309-y

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