Obese mammary tumour-bearing mice are highly sensitive to doxorubicin-induced hepatotoxicity

Abstract Background Breast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have reached epidemic proportions and contributes to the development of breast cancer. Doxorubicin (DXR) is a chemotherapeutic drug commonly used to...

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Bibliographic Details
Main Authors: Megan Sedeman, Claudia Christowitz, Louis de Jager, Anna-Mart Engelbrecht
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-022-10189-z