Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation

Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is a key player in cardiomyocyte calcium handling and also a classic target in the gene therapy for heart failure. SERCA2 expression dramatically increases during cardiomyocyte maturation in the postnatal phase of heart development, which...

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Bibliographic Details
Main Authors: Junsen Lin, Zhan Chen, Luzi Yang, Lei Liu, Peng Yue, Yueshen Sun, Mingming Zhao, Xiaoling Guo, Xiaomin Hu, Yan Zhang, Hong Zhang, Yifei Li, Yuxuan Guo, Erdan Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cardiomyocyte maturation
Cas9/AAV9-mediated somatic mutagenesis
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
heart failure
genetic mosaic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.864516/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.864516/full

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