CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin. Since a large energy barrier prevents microtubule nucleation in cells, the γ-tubulin ring complex is recruited to the centr...

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Bibliographic Details
Main Authors: Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
microtubule
CAMSAP
cryo-EM
TIRF
nucleation
LLPS
Online Access:https://elifesciences.org/articles/77365

Internet

https://elifesciences.org/articles/77365

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